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N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization

(PubMed) Bonetti A, Solito F, Carmosino G, Bargossi AM, Fiorella PL

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While more human data is needed, its mechanism aligns with many principles of functional and longevity medicine namely, supporting mitochondria, reducing inflammation, and improving insulin sensitivity