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GLP-1 (Semaglutide): Reduces appetite Slows gastric emptying Increases satiety Supports sustainable calorie reduction Average weight loss: Up to 15% in 68 weeks (NEJM 2021) GLP-1 + GIP (Tirzepatide): GLP-1 + GIP synergy boosts insulin sensitivity Enhances metabolic balance Further suppresses appetite and cravings Average weight loss: Up to 21% in 72 weeks (SURMOUNT-1) Compounded vs

GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity) work through multiple mechanisms to control blood glucose and reduce appetite

Antinociceptive effect of berberine on visceral hypersensitivity in rats

Commonly downregulated cytokine genes included WNT2B and BMP4, which attenuate inflammation and fibrosis, respectively (Fig