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After incubation of Glu or erastin for 8 h, PI and Hoechst 33342 at the concentration of 5 g/ml were treated for 10 min

proposed to replace the traditional nano-QSAR model with an approach called StructureActivity Prediction Networks (SAPNets), claiming it can effectively link NP structure with their toxicity through a series of layers built from nodes that correspond to predictive meta-models developed with machine learning techniques as well as Artificial Intelligence (Rybinska-Fryca et al., 2020)

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Mitochondrial respiratory chain complexes I (NADH-CoQ reductase complex), II (succinate dehydrogenase complex), III (cytochrome bc-1 complex) can, under different metabolic stress, produce ROS that damage the mitochondrial membrane, resulting in lipid peroxidation and ultimately leading to ferroptosis