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Using an extensively validated monoclonal antibody, one landmark study mapped the receptor to beta cells in the pancreas, the myocytes of the sinoatrial node in the heart, and the smooth muscle of arteries and arterioles in the kidney and lung

& Patel, S

One of the more important pathways is the inflammatory cascade: Metformin helps reduce inflammation, and the presence of inflammation is what triggers many of the negative downstream consequences of PCOS