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[16] [17] Early appetite changes represent the initial pharmacological effect, while measurable weight reduction reflects the cumulative impact of sustained caloric deficit over time

Respir Med

Initial therapy with the combination of JANUVIA and metformin provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo, to metformin alone, and to JANUVIA alone (Table 8, Figure 1)

Start your intake How Sitagliptin and Semaglutide Work Together Sitagliptin prolongs the action of endogenous GLP-1 and GIP by blocking DPP-4 degradation