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Its pathogenesis is unknown

However, when CV risk composition of all subjects in these groups was explored in this subgroup analysis, the results suggested a similarity irrespective of age

Indeed, germ-free mice exhibit reduced intestinal Glp1r expression and relative GLP-1 resistance (34) associated with elevated levels of circulating GLP-1 (36), consistent with an important role of the microbiota in determining GLP-1 sensitivity

Moreover, the MeD positively influences the composition and health of gut microbiota, also supporting the functional and anatomical integrity of the intestinal barrier and proper immune stimulation [189]