Hydroxyl radical ( OH) is taken into account as the most potent oxidant which, owing to its short half-life, very positive redox potential (close to +2 V) and high affinity for biomolecules, non-selectively oxidize DNA, proteins, lipids, amino acids, sugars, and metals, leading to damage or genetic instability
Ionization was achieved using electrospray in the positive ionization mode with an ion spray voltage of 4 kV
804 Lipid peroxide 4-HNE, which accumulates during myocardial I/R injury, promotes ubiquitination of GPX4 and induces cardiac ferroptosis by targeting the binding site of GPX4 and ovarian tumor deubiquitinase 5, while activation of aldehyde dehydrogenase 2 to degrade 4-HNE reduces myocardial ferroptosis
Yadav, V., Marracci, G., Lovera, J., Woodward, W., Bogardus, K., Marquardt, W., Shinto, L., Morris, C., & Bourdette, D