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Da es sich um eine Substitutionstherapie handelt, bestimmt der Arzt je nach Krankheitsbild die Zeitdauer der Anwendung unter Bercksichtigung der oben angegebenen Laborkontrollen

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Relevant to peptide drugs, immunogenicity can be attributed to several product- or process-related factors, such as aggregation, fibril formation, degradation during storage, and impurities introduced during the synthetic production of the active pharmaceutical ingredient (API) [4]

2010 Jul-Sep;9(3):263-8 Pedrazini Mc, Arajo Vc, Montalli Va