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Exclusion criteria for both the FEP and healthy control groups involved meeting criteria for a substance use disorder in the past year according to DSM-5 [36] criteria (this was based on self-report for controls, and in addition clinical assessment and urine drug screening done at the point of clinical assessment in suspected cases for patients), having a history of a major head injury (leading to a significant period of unconsciousness or seizures), having a significant, uncontrolled medical illness, or having any contraindications to undergoing MRI

GLP-1R agonists reach reward circuits, hinting at use in substance disorders

Indeed, there is almost a complete overlap between NAFLD and MASLD populations in several epidemiological studies, while only 5.3% of individuals with NAFLD did not fulfil the MASLD criteria in the population-based Nutrition Examination Survey (NHANES III) [6, 8]

Indeed, we found that i.c.v