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A homeostatic reduction in glutamate receptors and functional impairment of glutamatergic synapses in the hippocampus and medial prefrontal cortex have been reported in 2-subunit of GABA A receptor knockout mice, which exhibit a modest defect in GABAergic transmission (188)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Huang J, Xie B, Li Q, Xie X, Zhu S, Wang M, Peng W, Gu J

Interestingly, in renal clear cell carcinoma, IDO expressed by neovascularization endothelial cells is an inhibitory factor in tumor growth because it limits the flow of tryptophan from the blood to the tumor or produces tumor toxic substances (Riesenberg et al., 2007)