does ghk-cu cause receptor downregulation or tolerance

does ghk-cu cause receptor downregulation or tolerance ghk cu desensitization effectiveness over time The Effect of the Human Peptide on Gene Expression Relevant to Nervous System GLP-1 Peptide VS Small Molecule!?!?

Name: does ghk-cu cause receptor downregulation or tolerance ghk cu desensitization effectiveness over time The Effect of the Human Peptide on Gene Expression Relevant to Nervous System GLP-1 Peptide VS Small Molecule!?!?
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The intracellular domain has three portions: a juxtamembrane sequence that downregulates kinase activity which is followed by phosphorylation of Ser975 which is a catalytic region that promotes kinase activity leading to transphosphorylation of Tyr1234 and Tyr1235