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In fact, we observed an increase of metabolic flux by using D-glucose- 13 C 6 , which produced pyruvate containing three heavy-labeled carbons (M + 3-labeled pyruvate) and decreased of extracellular glucose level in the conditionate medium

32 The positive association between frequency of MTHFR -C677T and MTHFR -A1298C polymorphisms and latitude documented in the current study suggests that in areas closer to the equator, which are increasingly exposed to UVR, activity of the MTHFR enzyme reflects greater functional competency because of the absence of the MTHFR polymorphisms

Neuroprotection against excitotoxicity or brain damage is another role of lithium 21

However, their high costs and long-term implications raise important questions about their role in healthcare and insurance coverage