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In individuals with Covid-19, the ACE2 enzyme is dysfunctionaland ACE2 is needed to degrade bradykinin and block the bradykinin inflammatory receptor (BK1) that produces inflammatory NO

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These include so-called classical disorders like propionic academia (OMIM 606054) (53), various urea cycle disorders (89), and Sanfilippo syndrome (OMIM 252900, 252920) (90), as well as rarer disorders like succinic semialdehyde dehydrogenase deficiency (OMIM 271980) (91) and branched-chain ketoacid dehydrogenase kinase deficiency (OMIM 614901) (92)

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