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Plasma MDA (a lipid peroxidation marker) should decrease or remain stable despite ongoing weight loss if MDA rises while glutathione increases, oxidative stress exceeds antioxidant capacity and dosing adjustments are needed

As detailed in later sections, the DMRS spectra of one WT mouse was excluded due to failure in data processing, the fMRI data from one GLP-1R KO mouse was excluded due to being an outlier, and one GLP-1R KO mouse died during PET image acquisition