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It is vital, however, to keep in mind that while each stage is designated by a general time range following the APAP over-ingestion, clinical symptoms and laboratory results are dependent on the formulation (combined opiate-APAP preparations, extended-release, etc.) or doses of APAP ingested, including co-ingestions (i.e

High-dose glycine can reduce the therapeutic effect of clozapine and may potentiate sedation when taken with benzodiazepines, opioids, or other CNS depressants