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Effect of a single injection of gonadotropin-releasing hormone (GnRH) and human chorionic gonadotropin (hCG) on testicular blood flow measured by color doppler ultrasonography in male Shiba goats

The second trial, IMPACT 2, had a similar design, except that crossover to active therapy for the placebo arm took place at 24 weeks, although patients with active disease could enter an early escape at 16 weeks

Cognitive behavioral therapy (CBT) and interpersonal psychotherapy (IPT) remain first-line evidence-based treatments for BED, with robust data supporting their efficacy