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Understanding this context helps set realistic expectations and recognize that minor reactions are standard across injectable therapeutics

doi: 10.1038/s41590-019-0378-1 60 StephensonWDonlinLTButlerARozoCBrackenBRashidfarrokhiAet al

Over the past decade, although the mechanisms of DAMP production, their associated receptors, and downstream signaling pathways have been partially clarified, and although DAMPtargeted therapies have demonstrated potential in the treatment of inflammatory diseases and oncology, critical knowledge deficits still impede their clinical translation