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Half-life & frequency rationale No published human pharmacokinetic study of 5-Amino-1MQ exists, and the mouse efficacy study itself did not report half-life or bioavailability figures

Weight loss with Zepbound is gradual and requires patience

[1] Other rare side effects noted (mostly in older literature or high-dose use) include: polycythemia vera and peripheral vascular thrombosis in patients receiving repeated injections (though these associations are not well understood, they were listed in prior product literature as possible adverse events)

However, it's important to note that for pernicious anaemia or deficiency with neurological involvement, intramuscular hydroxocobalamin injections remain the first-line treatment in the UK, as recommended by NICE and the British Society for Haematology