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Clinical and epidemiological studies included in this review offer additional perspectives on potential human health implications

12%).Nausea was the most common side effect associated with pramlintide but was generally mild to moderate and occurred in fewer than 10% of participants during the extension phase

This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]

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