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2) reduce the dose of oral minoxidil to 1.25 mg or 1.875 mg and add spironolactone 50-100 mg once daily if there are no contraindications and the patient accepts the potential side effects

Body fat serves as insulation, helping to maintain core body temperature and reduce heat loss to the environment

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(7) Kynurenic acid: Kynurenic acid is a metabolite of the kynurenine pathway, plays a significant role in both vascular inflammation and macrophage activation