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In terms of statistical analysis, changes of the density of adipose tissue from baseline to week 26 were compared via Wilcoxon matched-pairs signed-rank test

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The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle primum non nocere (Micallef et al., 2020a)

However, even in this highly controlled medical context, challenges remain