Exogenous GLP-1 improves gastric compliance in a dose-dependent manner (Schirra et al., 2002), reduces the frequency and amplitude of gastric antrum and duodenum contraction, inhibits the contractile force of gastric antrum and duodenum, increases pyloric tension, and stimulates pyloric tetanic and phase motion (Schirra et al., 2000)
In ophthalmic clinical trials (RGN-259), the topical thymosin beta-4 formulation was well tolerated, with no serious adverse effects attributable to the treatment
The specific explanation for exclusion criteria were as follows: (3) uncertainty regarding the timing of the initial prescription of oral semaglutide, (4) rapid dose escalation of oral semaglutide during hospitalization, (5) potential confounding effects on HbA1c levels, and (6, 7) difficulties in accurately assessing the therapeutic effects of oral semaglutide
Individual experience varies, which is why some people who cannot tolerate one do fine on the other