60,63 Additionally, the nervous system has negative regulatory effects on insulin secretion, as catecholamines, through alpha2-adrenoreceptors, are known to usually inhibit insulin release during exercise, by acting downstream on signalling pathways activated by nutrient secretagogues
When to contact your GP, diabetes team, or healthcare professional: Severe or persistent nausea and vomiting preventing adequate fluid or food intake Signs of dehydration (dark urine, dizziness, reduced urination) Severe abdominal pain, particularly if accompanied by vomiting, or right upper abdominal pain with fever Symptoms of hypoglycaemia that don't resolve with usual treatment Unexplained weight loss exceeding clinical targets Changes in mood or suicidal thoughts Any concerns about medication tolerance or effectiveness The MHRA continues to monitor the safety profile of incretin medications through the Yellow Card scheme
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