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Inhibition of p53 disrupts these protective cellular mechanisms, allowing APAP-induced damage to progress unchecked, resulting in severe liver injury

As with the prior trial, no liver safety concerns were seen, Lilly said

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Storage Lyophilizate (dry powder before reconstitution) 2 to 3 years at 20 C (freezer) 6 to 12 months at 2 to 8 C (refrigerator) Up to 30 days at room temperature (up to 25 C), protect from light and moisture After reconstitution (peptide in solution with bacteriostatic water) Up to 28 days at 2 to 8 C , protected from light After this period degradation products (= broken fragments of the molecule, which do not function) can rise significantly Sterile water without preservative shortens stability to 7 to 10 days Practical storage rules Allow the vial to warm to room temperature (15 to 20 min) before opening