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Relevant tunnels were identified from the top-ranked tunnels identified by CAVER as those tunnels which traversed and filled the length of the proteins tunnel without escaping to the protein surface through a side gap or by overflowing the interior tunnel

During this process, PLA particles were colonized by gut microbes, forming surface biofilms and increasing pullulanase activityan enzyme that degrades branched polysaccharidesthe authors suggested this may have broken down PLA into smaller carbon-rich molecules, potentially supporting Bifidobacterium growth, without triggering pathogenic overgrowth or inflammatory responses (Jimnez-Arroyo et al., 2023)

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