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This condition is known as cerebral folate deficiency, and has been implicated as a reversible cause of autism

This dynamic regulation allows active Vitamin D to intervene during the later stages of T cell activation, where VDR binds to Vitamin D response elements (VDREs) in the genome, reshaping the T cell transcriptional landscape and modulating cytokine expression, migratory behavior, and metabolic programming [160,161,162]

These effects can occur during treatment and are typically managed through dose adjustment, medical monitoring, and clinician-guided supportive care rather than self-management