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Ipamorelin does not suppress somatostatin release (unlike GHRH) and has minimal affinity for GHS-R1a splice variants associated with cortisol and prolactin release, explaining its superior endocrine selectivity profile

NAD Preservation: Supports higher intracellular NAD availability, promoting mitochondrial function and cellular energy production

Clin Endocrinol (Oxf) 1998;49:6367

This confirms that variables selected for matching (age, sex, time from diagnosis to baseline, onset), in combination with multivariable adjustment for unbalanced covariates in the primary analysis, allowed a good control of confounding