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doi: 10.3389/fpain.2025.1593908 Received 14 March 2025 Accepted 28 April 2025 Published 13 May 2025 Volume 6 - 2025 Edited by Otilia Obreja, Zentrum fr Schmerz und Stresserkrankungen, Switzerland Reviewed by Evelyne Silva Brum, Federal University of Rio Grande do Sul, Brazil Updates Copyright 2025 Ho, Ryan and Holle

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm