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The mechanism may be related to the decrease of forkhead-box class O (FOXO) transcription factor expression in chondrocytes, thus weakening the cell's resistance to oxidative stress [41]

Melanocyte-stimulating hormone is a derivative of the precursor proopiomelanocortin, an agonist on the melanocortin-1 receptor that promotes formation of eumelanin

Phentermine should not be taken by people with the following conditions: History of heart problems, such as coronary artery disease, stroke, arrhythmias, heart failure, or uncontrolled high blood pressure Hyperthyroidism Glaucoma History of drug abuse Agitation Pregnancy or breastfeeding Allergic reaction to phentermine or a similar drug Because of the risk of severely high blood pressure, phentermine is also contraindicated in those who take or have taken MAOIs within the last 14 days