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Non-pharmacological interventions such as sauna therapy and hyperbaric oxygen therapy, along with experimental strategies involving gene editing and stem cell therapies, present innovative frontiers in longevity medicine

While native IGF-1 within physiological ranges appears safe, supraphysiological stimulation of IGF-1 receptor signaling through exogenous administration of potent analogs like IGF-1 DES could theoretically promote growth of existing pre-malignant or malignant cells, accelerate tumor progression, or support metastatic spread by enhancing cell survival and proliferation while inhibiting apoptosis