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23, NP4: Fig

In this regard, any small molecule oral GLP-1 receptor agonist must show cardiovascular benefits, which is one of the most distinctive beneficial effects, particularly for long-acting GLP-1 receptor agonists [35,4749]

Effective implementation depends on systematic assessment, personalization, and careful integration with conventional pharmacotherapy

Clinical features of children with GDH-HI include persistent mild hyperammonemia, hypoglycemia after fasting or high protein (especially leucine) diets, and neuroglycopenic symptoms including seizures