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The mechanisms underlying weight regain are multifactorial and include metabolic adaptation with decreased energy expenditure, hormonal changes affecting appetite regulation, anatomical alterations such as gastric pouch or stoma dilation, and psychosocial factors including maladaptive eating behaviors

The research was funded by the US National Institute of Child Health and Development, the EU's Horizon 2020 research and innovation program, NordForsk and the Research Council of Norway