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When comparing phentermine vs semaglutide, the STEP 1 trial reported that participants who stopped semaglutide medication after 68 weeks regained roughly two-thirds of their lost weight within one year

That approval status is a hard regulatory fact, and it is the single biggest reason a CagriSema-versus-tirzepatide comparison is not a comparison of equals: one product has cleared a full regulatory efficacy-and-safety review, and the other has not yet

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