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Many patients achieve their optimal weight loss rate at a moderate maintenance dose, beyond which further increases yield minimal additional benefit

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As a result, they may experience a resurgence of appetite and food intake, coupled with fewer calories burned at rest, leading to weight regain

The Nrf2-independent effect of these inducers could result from their ability to activate additional transcription factors that are also able to increase GST expression, such as the pregnane-X-receptor (PXR), which in turn activates ARE signaling (reviewed in [32])