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Methods We performed an online electronic search for relevant English literature on PubMed and Web of Science databases, with the keywords of dipeptidyl peptidase 1, cathepsin C, cathepsin C structure, cathepsin C maturation, cathepsin C loss-of-function, neutrophil serine proteases and bronchiectasis, neutrophil serine proteases and cathepsin C, neutrophil serine proteases and DPP-1, DPP-1 inhibitors, cathepsin C inhibitors, DPP-1 inhibitors and bronchiectasis, cathepsin C inhibitors and bronchiectasis