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Besides the activation loop (A-loop), the second most common site for amino acid substitutions is the GSGSFG phosphate-binding loop (P-loop) at residues 464-469 (94)

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Science 338(6108):818822 Uyuklu T, Ural AU, Sarper M, Avcu F, Baran Y, Elci P et al (2007) A study of multiple drug resistance mechanisms improved against Bortezomib on multiple myeloma cell lines in vitro