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Solucin de referencia: Tomar una cantidad apropiada de la sustancia de referencia de impureza I, pesarla con precisin, disolverla en agua y diluirla cuantitativamente con fase mvil para preparar una solucin que contenga aproximadamente 25 g por 1 mL

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Although these therapies have effectively managed symptoms and decelerated disease progression, long-term use is often associated with severe adverse effects, including increased infection risk, osteoporosis, metabolic disorders, and the likelihood of malignant tumors (6, 7)