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The 2023 New England Journal of Medicine publication described a randomized, double-blind, placebo-controlled Phase 2 trial in adults with obesity or overweight with at least one related condition

Ischemia-reperfusion protection : Hydrogen effectively neutralizes the burst of free radicals during reperfusion when hydroxyl radicals are produced in abundance

To provide a more thorough theoretical foundation for treating disorders associated to TMAO, larger-scale clinical trials are needed to validate TMAOs potential as a biomarker for various diseases along the gut-organ axis

These therapies require a prescription and medical guidance