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Over approximately 3 years: Metformin group: 2.1 kg (4.6 pounds) average weight loss Lifestyle group: 5.6 kg (12.3 pounds) average weight loss Placebo group: 0.1 kg (0.2 pounds) average weight loss Meta-analyses: Systematic reviews of metformin for weight loss show: Average weight loss of 1-3 kg (2-7 pounds) compared to placebo Effects are modest and variable between individuals Weight loss tends to occur primarily in the first year, then stabilizes Percentage terms: Metformin typically produces 2-5% body weight loss in most studies, though some patients lose more and many lose essentially nothing