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Tirzepatide activates both, offering enhanced anti-inflammatory effects

The cardiovascular benefits of weekly injected GLP-1 receptor agonists have been proven in SUSTAIN-6 (Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes), REWIND (Researching Cardiovascular Events with a Weekly Incretin in Diabetes) and The Harmony outcomes trials

GLP-1 acts on the GLP-1R, activating multiple intracellular signaling pathways, including the cAMP/PKA pathway, the PI3K/Akt signaling pathway, and pathways related to anti-inflammatory and anti-oxidative stress responses, among others

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