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GLP-1 receptor agonists (semaglutide, liraglutide) increase gallbladder event rates compared to placebo, primarily due to rapid weight loss rather than the medication itself

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published in Diabetes, Obesity and Metabolism examined data from 52 randomized controlled trials involving over 75,000 participants treated with GLP-1 receptor agonists

Risk: Novo has been steadily losing ground to Mounjaro and Zepbound, and Jim Cramer recently noted Lilly's pipeline could deliver "the unassailable knockout punch against Novo Nordisk because it's got fat busting without muscle crunch." A value trap is the obvious failure mode