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52-59 Maintenance of response differs across the different agents, but generally 50 to 80% of patients who respond remain in clinical remission at 12 months and beyond

NAC has 4050% oral bioavailability and directly replenishes the rate-limiting substrate for glutathione synthesis

that is, when there is no reason for suspicion based upon known environmental history that toxins may be elevated, is inappropriate because of the possibility that false positives may lead to inappropriate, ineffective therapies and their attendant risks [99]