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Although a plethora of tumor cell mechanosensors have been identified, including focal adhesions, ion channels, actin cytoskeleton, nuclear proteins, and transcription factors, more research is needed to uncover how breast cancer cells convert biophysical signals into biochemical cues to mediate short- and long-term mechanoresponses ( Table 5 )

This biomimetic approach facilitated BBB penetration and specific homing to glioblastoma, resulting in pronounced growth inhibition of temozolomide-resistant tumors [193]

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