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In contrast, resmetirom (Rezdiffra) received FDA approval in 2024 specifically for noncirrhotic NASH with F2F3 fibrosis
They offer a systemic approach, meaning they address symptoms throughout the body
Male rats with PTSD-like behaviors showed elevated p -cresol (a neurotoxic metabolite linked to overgrowth of Ruminococcaceae and Lachnospiraceae ) in prefrontal cortex, leading to dopaminergic dysfunction with increased DA, increased dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), and significantly elevated DA D3 receptor expression compared to controls (Laudani et al., 2023)
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