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Sex differences in chronic obstructive pulmonary disease mechanisms
R 2 is H, C 1 -C 6 alkyl, C 1 -C 6 alkyl-OR 6 , C 1 -C 6 alkylC 3 -C 6 cycloalkyl, C 1 -C 6 alkylC 2 -C 7 heterocycloalkyl, C 1 -C 6 alkyl-CO 2 R 6 , optionally substituted C 1 -C 6 alkylC 6 -C 10 aryl, or optionally substituted C 1 -C 6 alkylC 3 -C 9 heteroaryl
Moreover, KPV has been investigated in preclinical models for potential anti-inflammatory effects, primarily through inhibition of intracellular NF-B and MAP kinase signaling pathways, independent of melanocortin receptor mechanisms
[DOI] [PubMed] [Google Scholar] 44.Strinic D, Belosic Halle Z, Luetic K, Nedic A, Petrovic I, Sucic M, Zivanovic Posilovic G, Balenovic D, Strbe S, Udovicic M, Drmic D, Stupnisek M, Lovric Bencic M, Seiwerth S, Sikiric P
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