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Sikora SK, Spady D, Prosser C, El-Matary W

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We hypothesize that (i) the slow inhibition observed in the biochemical assay with the recombinant protein with some of the compounds is due to their preferential binding to a slowly populated conformer of the NADP + -TGR(H) complex and (ii) this conformer is already populated in the worm cell interior accounting for the more rapid inhibition of TGR observed in ex vivo worms with the slow inhibitors

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"I'm very confident about CagriSema," CEO Lars Fruergaard Jrgensen told shareholders at the firm's Annual General Meeting in Copenhagen, Denmark

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de Leeuw, E., Li, C., Zeng, P., Li, C., de Diepeveen, B.M., Lu, W.Y., et al., FEBS Lett

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