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In this multicenter study of over 250,000 hospitalizations, use of novel diabetes medications prior to discharge was rare, raising the concern for systematic underutilization after discharge, Michael Fralick, PhD, MD, MSc, assistant professor in the department of medicine at University of Toronto and clinical scientist at Sinai Health in Toronto, and colleagues wrote

Mutation of an evolutionarily conserved tyrosine residue in the active-site of a human class alpha-glutathione transferase