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This protective effect may result from semaglutides modulation of insulin signaling through the PI3K/Akt/GSK3 axis, thereby reducing -amyloid formation 44,45

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N Engl J Med 357:23592370 [DOI] [PubMed] [Google Scholar] Falutz J, Allas S, Mamputu JC, Potvin D, Kotler D, Somero M, Berger D, Brown S, Richmond G, Fessel J, Turner R, Grinspoon S 2008 Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation