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these should be reported to healthcare providers for appropriate investigation

It is acknowledged that the stimulation of signal transducers and activators of transcription 3 (STAT3) is essential for the transformation into the M2 subtype, whereas the activation of STAT1 is a crucial determinant for the M1 subtype [85]

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In the future, it is recommended to include a more significant number of follow-up studies based on unified criteria to understand better the relationship between obesity and psychiatric disorders, including suicide, anxiety and depression [36, 37]