Nausea (most common, typically dose-dependent and transient) Diarrhea or constipation during dose escalation Vomiting, especially when starting or increasing dose Reduced appetite and early satiety Injection site reactions (redness, bruising) Fatigue, particularly in early weeks Rare: Pancreatitis discontinue immediately with severe abdominal pain Rare: Thyroid C-cell effects (contraindicated with MEN2 or thyroid cancer history) AOD-9604 is a modified C-terminal fragment (residues 176191, Tyr-hGH177-191) of human growth hormone, studied for lipolytic and anti-obesity properties
Future directions include large-scale, randomized trials, combining therapies, and biomarker studies to validate findings and identify patient subgroups benefiting from antioxidant supplementation
Chen J, Wang Z, Liu S, Zhao R, Chen Q, Li X, et al
Data primarily derived from animal studies and early experimental trials